August 02, 2024

Coenzyme Q-10 (Ubiquinone)

What is Coenzyme Q10 (Ubiquinone)?

Coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble compound found in virtually every cell of the body. It plays a critical role in the production of energy in the form of adenosine triphosphate (ATP) within mitochondria. CoQ10 also acts as a potent antioxidant, protecting cells from oxidative damage.

What are the Benefits of Coenzyme Q10?

  • Energy Production: Enhances cellular energy production by aiding in ATP synthesis.
  • Heart Health: Supports cardiovascular health and may improve outcomes in heart failure patients.
  • Antioxidant Properties: Protects cells from oxidative stress and damage.
  • Neurological Health: May slow the progression of neurodegenerative diseases like Parkinson's.
  • Exercise Performance: Improves physical performance and reduces fatigue.

What Research is on Coenzyme Q10?

Research has shown that CoQ10 supplementation can improve heart function, reduce the frequency of migraines, and slow the progression of neurodegenerative diseases. It is particularly beneficial for patients with heart failure, where it can improve symptoms and quality of life. Studies also suggest CoQ10's role in enhancing energy production and reducing oxidative stress in various conditions​.

What is the Mechanism of Action for Coenzyme Q10?

CoQ10 participates in the electron transport chain within mitochondria, which is essential for ATP production. As an antioxidant, it helps neutralize free radicals, reducing oxidative damage to cells. CoQ10 also regenerates other antioxidants, such as vitamin E, enhancing its protective effects against oxidative stress.

What is the Typical Dosage of Coenzyme Q10?

The typical dosage of CoQ10 varies depending on the condition being treated:

  • General Health: 100-200 mg per day.
  • Heart Failure: 200-600 mg per day, divided into multiple doses.
  • Migraine: 100 mg three times a day.
  • Neurodegenerative Diseases: Higher doses up to 1,200 mg per day have been used in studies.

What Foods are Rich in Coenzyme Q10?

  • Meat: Particularly organ meats like heart, liver, and kidney.
  • Fish: Fatty fish such as salmon, mackerel, and sardines.
  • Nuts and Seeds: Peanuts, sesame seeds, and pistachios.
  • Vegetables: Spinach, broccoli, and cauliflower.
  • Legumes: Soybeans and lentils.

Sood, Brittany, et al. “Coenzyme Q10.” StatPearls, StatPearls Publishing, 30 January 2024.

“Coenzyme Q10.” LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, National Institute of Diabetes and Digestive and Kidney Diseases, 20 April 2024.