DHEA (dehydroepiandrosterone)
What is DHEA?
DHEA (dehydroepiandrosterone) is a steroid hormone produced by the adrenal glands, gonads, and brain. It serves as a precursor to other hormones, including testosterone and estrogen. The levels of the ingredient peak in early adulthood and gradually decline with age. It is available as a dietary supplement, often marketed for its potential to improve mood, energy levels, and overall well-being.
What are the benefits of DHEA?
Hormonal Balance: It helps maintain hormone levels, especially as they decline with age.
Improved Mood and Cognitive Function: It may enhance mood, reduce symptoms of depression, and improve cognitive function.
Bone Health: DHEA supports bone density and may reduce the risk of osteoporosis.
Anti-Aging Effects: It is believed to have anti-aging properties by promoting skin health and reducing signs of aging.
Immune System Support: It may enhance immune function and increase resistance to infections.
Improved Libido and Sexual Function: It can help improve libido and sexual function, particularly in older adults.
What research is on DHEA?
Research on DHEA as produced mixed results. Some studies have demonstrated its benefits in improving mood, cognitive function, and bone density, particularly in postmenopausal women. Other research indicates potential benefits for adrenal insufficiency and certain autoimmune conditions. However, the long-term safety and efficacy of the supplement require further investigation, and its effects can vary depending on individual health conditions and dosages used.
What is the mechanism of action for DHEA?
The mechanism of action for DHEA involves several pathways:
- Hormone Precursor: It serves as a precursor to androgens and estrogens, contributing to the production of these sex hormones.
- Receptor Binding: It interacts with androgen receptors and may influence gene expression related to hormone regulation.
- Neuroprotective Effects: It has neuroprotective properties, potentially improving brain function and mood through its interaction with neurotransmitter systems.
- Immune Modulation: It modulates immune responses by influencing cytokine production and immune cell activity.
What is the typical dosage of DHEA?
The typical dosage of DHEA can vary widely based on the intended use and individual needs. Common dosages range from 25 mg to 50 mg per day for general health and anti-aging purposes. For specific medical conditions, higher doses may be used under medical supervision. It is important to start with a lower dose and gradually increase it if needed, and to consult with a healthcare provider before beginning supplementation to ensure safety and appropriate use.
What foods are rich in DHEA?
DHEA is not found in foods as it is a hormone produced by the body. There are no dietary sources of it, and it cannot be obtained through food consumption. To increase levels, supplementation is typically required. Maintaining overall health through a balanced diet, regular exercise, and stress management can support the body's natural production of the ingredient.
Rutkowski, Krzysztof et al. “Dehydroepiandrosterone (DHEA): hypes and hopes.” Drugs vol. 74,11 (2014): 1195-207. doi:10.1007/s40265-014-0259-8
Morales, A J et al. “The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women.” Clinical endocrinology vol. 49,4 (1998): 421-32. doi:10.1046/j.1365-2265.1998.00507.x