BENFOTIAMINE

What is Benfotiamine?

Benfotiamine is a synthetic derivative of thiamine (Vitamin B1), belonging to the family of fat-soluble B-vitamins. It is structurally similar to thiamine but is more bioavailable and can penetrate cell membranes more effectively than thiamine itself.

WHAT ARE THE BENEFITS OF BENFOTIAMINE?

Diabetes Management: Benfotiamine has been studied for its potential role in managing diabetes by improving glucose metabolism and reducing the complications associated with high blood sugar levels.

Neuropathy: It may help alleviate symptoms of diabetic neuropathy, such as tingling or numbness in the extremities, by supporting nerve health and function.

Antioxidant Properties: Benfotiamine exhibits antioxidant effects that protect cells from oxidative stress and reduce inflammation throughout the body.

Eye Health: Studies suggest that Benfotiamine may support eye health and protect against diabetic retinopathy, a common complication of diabetes affecting the eyes.

Cardiovascular Support: It may help improve vascular function and reduce the risk of cardiovascular diseases by supporting endothelial function and reducing oxidative damage.

WHAT RESEARCH IS ON BENFOTIAMINE?

Research on Benfotiamine has focused on its therapeutic potential and mechanisms of action

Diabetes and Glucose Metabolism: Clinical studies indicate that Benfotiamine supplementation can improve insulin sensitivity, reduce blood sugar levels, and lower markers of oxidative stress in individuals with diabetes.

Neuropathy and Nerve Health: Benfotiamine has been studied for its neuroprotective effects, showing promise in reducing symptoms of diabetic neuropathy and supporting nerve regeneration.

Antioxidant and Anti-inflammatory Effects: Research suggests that Benfotiamine reduces oxidative stress and inflammation, which are implicated in various chronic diseases and aging processes.

Eye Disorders: Studies in animal models and clinical trials have explored Benfotiamine potential in preventing or delaying diabetic retinopathy and other eye complications.

WHAT IS THE MECHANISM OF ACTION FOR BENFOTIAMINE?

Bioavailability: Benfotiamine is lipid-soluble and can cross cell membranes more efficiently than thiamine, allowing for higher intracellular concentrations and enhanced bioavailability.

Glycation Inhibition: It inhibits the formation of advanced glycation end-products (AGEs), which contribute to tissue damage and complications in diabetes.

Activation of Transketolase: Benfotiamine activates the enzyme transketolase, which plays a key role in the pentose phosphate pathway and helps reduce oxidative stress.

Neuroprotection: Benfotiamine supports nerve health by promoting myelin sheath formation, reducing nerve inflammation, and enhancing nerve cell regeneration.

WHAT IS THE TYPICAL DOSAGE OF BENFOTIAMINE?

Typical dosages of Benfotiamine in dietary supplements range from 150 mg to 600 mg per day, divided into two or three doses. Dosage recommendations may vary based on individual health conditions and response to treatment.

WHAT FOODS ARE RICH IN BENFOTIAMINE?

Benfotiamine is a synthetic form of thiamine and is not naturally found in food sources. It is primarily available as a dietary supplement for therapeutic use.

In summary, Benfotiamine offers potential benefits for managing diabetes, supporting nerve health, protecting against oxidative stress, and promoting overall cardiovascular and eye health. Its enhanced bioavailability and specific mechanisms of action make it a valuable supplement for individuals seeking to address specific health concerns related to thiamine deficiency or diabetes-related complications.

 

Xie, Feifan et al. “Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride.” Journal of clinical pharmacology vol. 54,6 (2014): 688-95. doi:10.1002/jcph.261

Balakumar, Pitchai et al. “The multifaceted therapeutic potential of benfotiamine.” Pharmacological research vol. 61,6 (2010): 482-8. doi:10.1016/j.phrs.2010.02.008